CARD11 p.R555Gfs*45 Reference Standard
CBP10742
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| Introduction | |
| Format | Genomic DNA |
| Description | CARD11, caspase recruitment domain family, member 11, is a component of a scaffold complex that regulates NFKB activity . Activating mutations in the CARD11 coiled-coil domain activate NFKB and have been identified in hematological cancers, including diffuse large B cell lymphoma and may confer resistance to ibrutinib. |
| Technical Data | |
| DNA Change | c.1663del |
| AA Change | p.R555Gfs*45 |
| Mutation type | Deletion - Frameshift |
| Zygosity | Heterozygous |
| Allelic Frequency | 65.21%(DdPCR) |
| Transcript | ENST00000396946.4 |
| Cosmic ID | COSM1450247 |
| Chr position(GRCh37) | chr7:2968329 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
